Sun Y, Chen M H, Zhang Y X, Xiao H, Liu H Y, Chen X, Zeng Y
Institute of Virology, Hubei Medical College, Wuhan.
Zhonghua Zhong Liu Za Zhi. 1987 Sep;9(5):345-7, 20.
The promoting effect of the Chinese medicinal herb, Wikstroemia chamaedaphne and Tung oil extracts (WC and HHPA) on carcinoma of uterine cervix induced by HSV-2 or MCA in mice was studied. The results showed that WC and HHPA extracts were not carcinogenic themselves. After carcinogen HSV-2 and MCA treatment, WC and HHPA were added separately. The inducing rates by HSV-2 increased from 7.4% to 21.1% and 26.3%, those by MCA increased from 56.5% to 82.8% and 84.4%. There was a significant difference between the combined groups and groups with HSV-2 or MCA only. The experimental results suggest that these two kinds of extracts play a promoting effect on carcinogenesis. The relation between the carcinogenesis of uterine cervix or nasopharynx and WC or HHPA extracts is discussed.
研究了中药黄芫花及桐油提取物（WC和HHPA）对单纯疱疹病毒2型（HSV - 2）或甲基胆蒽（MCA）诱发的小鼠宫颈癌的促进作用。结果表明，WC和HHPA提取物本身无致癌性。在致癌剂HSV - 2和MCA处理后，分别加入WC和HHPA。HSV - 2诱发率从7.4%分别增至21.1%和26.3%，MCA诱发率从56.5%分别增至82.8%和84.4%。联合用药组与单纯HSV - 2或MCA组之间有显著差异。实验结果提示，这两种提取物对致癌过程有促进作用。文中还讨论了宫颈癌或鼻咽癌的发生与WC或HHPA提取物之间的关系。
