Gao J Z
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1990 Nov;12(6):453-6.
From 1958 to 1984, 13 cases were diagnosed as endometrial stromal sarcoma in our hospital, 9 of whom having complete data and been followed for over 5 years were analysed. The results indicated that degree of cellular atypia was a major factor related to prognosis. According to the degree of cellular atypia with consideration of cellular mitotic rate, the tumors were divided into two types: low and high grade malignancies. The former was likely to develop recurrence in the pelvis whereas the latter was prone to distant metastasis. There was no definite relation between the time and initial site of recurrence or metastasis and the stage of the lesion. Operation is the treatment of choice for primary as well as recurrent lesions. The operation should be total hysterectomy and bilateral salpingo-oophorectomy with removal of all visible tumor tissues. In this series, 5 patients received prophylactic postoperative pelvic radiation, none developed local recurrence and 3 of them have survived for 13-19 years free of tumor. Two of 3 treated with postoperative chemotherapy developed recurrence and died 3 months and 4 years after chemotherapy, respectively.
1958年至1984年，我院共诊断出13例子宫内膜间质肉瘤，其中9例资料完整且随访超过5年，对其进行了分析。结果表明，细胞异型性程度是与预后相关的主要因素。根据细胞异型性程度并结合细胞有丝分裂率，将肿瘤分为两型：低级别和高级别恶性肿瘤。前者易在盆腔复发，而后者易发生远处转移。复发或转移的时间及初始部位与病变分期之间无明确关系。手术是原发性及复发性病变的首选治疗方法。手术应行全子宫切除术及双侧输卵管卵巢切除术，并切除所有可见肿瘤组织。在本系列研究中，5例患者术后接受了预防性盆腔放疗，均未发生局部复发，其中3例已无瘤存活13至19年。3例接受术后化疗的患者中，2例分别在化疗后3个月和4年复发并死亡。
