Korting H C, Zienicke H, Schäfer-Korting M, Braun-Falco O
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, FRG.
Eur J Clin Pharmacol. 1990;39(4):349-51. doi: 10.1007/BF00315408.
The effect of a liposomal preparation of beta-methasone dipropionate (0.039%, BDP) has been compared to that of a commercial propylene glycol-gel containing 0.064% BDP in a double-blind, randomized, paired trial lasting 14 d in 10 patients with atopic eczema and 10 patients with psoriasis vulgaris. In eczema, the liposome preparation tended to reduce erythema and scaling more than the conventional gel, the difference in the latter parameter being significant on Day 7. There was greater improvement of psoriasis on the side treated with the reference gel. Hence, liposome encapsulation of BDP may increase the antiinflammatory action but not the antiproliferative effect. Since inhibition of mitotic activity is linked to the atrophogenicity of topical corticosteroids, the results suggest that liposome encapsulation may improve the benefit-risk ratio in eczema.
在一项为期14天的双盲、随机、配对试验中，将二丙酸倍他米松脂质体制剂（0.039%，BDP）与含0.064%BDP的商用丙二醇凝胶的效果进行了比较，该试验涉及10名特应性皮炎患者和10名寻常型银屑病患者。在湿疹患者中，脂质体制剂比传统凝胶更倾向于减轻红斑和脱屑，后一参数在第7天的差异具有显著性。使用参比凝胶治疗的那一侧银屑病改善更明显。因此，BDP的脂质体包封可能会增强抗炎作用，但不会增强抗增殖作用。由于有丝分裂活性的抑制与局部皮质类固醇的萎缩性有关，结果表明脂质体包封可能会改善湿疹的效益风险比。
