Schmid M H, Korting H C
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München.
Clin Investig. 1993 Aug;71(8):649-53. doi: 10.1007/BF00184495.
Atopic dry skin characterized by a defect of the barrier function as determined by transepidermal water-loss measurements at the ultrastructural level shows an increase in membrane-coating granules (MCGs). MCGs are lamellar, ovoid organelles appearing in the stratum spinosum and stratum granulosum. MCGs consist of stacks of small parallel disks that are extruded and fuse to continuous lamellae. Liposomes, i.e., unior multilamellar vesicles composed of alternating lipid and water phases are structurally similar. Moreover, they also can form continuous lamellae. While phospholipids are generally used for liposome production, skin lipids and in particular ceramides can also be used. These lipids also seem to be the major components of MCGs. Hence, it seems advisable to use liposomes made of such lipids in the treatment of atopic dry skin. Apart from the probable inherent effect liposomes of this type may also apply particularly well for the delivery of active components.
特应性干性皮肤的特征是屏障功能缺陷，这是通过超微结构水平的经表皮水分流失测量确定的，其膜被颗粒（MCGs）增加。MCGs是出现在棘层和颗粒层的层状、卵圆形细胞器。MCGs由堆叠的小平行盘组成，这些盘被挤出并融合成连续的薄片。脂质体，即由交替的脂质和水相组成的单室或多室囊泡，在结构上与之相似。此外，它们也可以形成连续的薄片。虽然通常使用磷脂来生产脂质体，但皮肤脂质，尤其是神经酰胺也可以使用。这些脂质似乎也是MCGs的主要成分。因此，在特应性干性皮肤的治疗中使用由这类脂质制成的脂质体似乎是可取的。除了可能的内在作用外，这种类型的脂质体也可能特别适用于活性成分的递送。
