Edeki T, Johnston A, Turner P
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London.
Eur J Clin Pharmacol. 1990;39(4):405-7. doi: 10.1007/BF00315420.
The influence of 2 weeks oral intake of nifedipine (2 x 20 mg) on the oxidative metabolism of antipyrine was investigated in 12 normal volunteers, who had 1050 mg antipyrine solution orally before and after the course of nifedipine. There were no statistically significant differences in the saliva pharmacokinetic parameters of antipyrine on both occassions. However, the metabolite profile of antipyrine in urine showed a significant reduction in the amount of norantipyrine excreted after compared to that before nifedipine administration (16.5 vs 19.6%). This may have implications for drugs that share a similar demethylation pathway with norantipyrine.
在12名正常志愿者中研究了口服硝苯地平（2×20mg）两周对安替比林氧化代谢的影响，这些志愿者在硝苯地平疗程前后均口服1050mg安替比林溶液。两次测量时安替比林的唾液药代动力学参数无统计学显著差异。然而，与硝苯地平给药前相比，尿液中安替比林的代谢产物谱显示去甲安替比林排泄量显著减少（16.5%对19.6%）。这可能对与去甲安替比林具有相似去甲基化途径的药物有影响。
