人体内安替比林三种主要氧化代谢物的体内和体外生成速率比较。
Comparison of the in vivo and in vitro rates of formation of the three main oxidative metabolites of antipyrine in man.
作者信息
Boobis A R, Brodie M J, Kahn G C, Toverud E L, Blair I A, Murray S, Davies D S
出版信息
Br J Clin Pharmacol. 1981 Dec;12(6):771-7. doi: 10.1111/j.1365-2125.1981.tb01305.x.
Abstract
1 The metabolism of antipyrine to its three main oxidative metabolites, 4-hydroxyantipyrine, 3-hydroxymethylantipyrine and norphenazone was investigated in vivo and in vitro in separate groups of subjects with normal hepatic function and in the same group of patients with suspected liver disease. 2 The rank order for the rate of formation of the three metabolites of antipyrine was similar in vivo and in vitro. 3 There was no significant correlation between the rates of formation of any pair of antipyrine metabolites either in vivo or in vitro. 4 Despite this there was a significant correlation between the in vivo and in vitro rates for formation of each of the three metabolites in the same group of patients. 5 It is concluded that determination of rates of formation of antipyrine metabolites from their excretion in urine provides an indication of the activity of the enzymes involved in their formation.
摘要
- 在肝功能正常的不同组受试者以及同一组疑似肝病患者中，对安替比林代谢为其三种主要氧化代谢物4 - 羟基安替比林、3 - 羟甲基安替比林和去甲非那宗的过程进行了体内和体外研究。2. 安替比林三种代谢物的生成速率在体内和体外的排序相似。3. 无论是在体内还是体外，任意一对安替比林代谢物的生成速率之间均无显著相关性。4. 尽管如此，同一组患者体内和体外三种代谢物各自的生成速率之间存在显著相关性。5. 得出结论，通过尿液排泄情况测定安替比林代谢物的生成速率可反映参与其生成的酶的活性。
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