Lalonde R
University of Quebec, Department of Psychology, Montreal, Canada.
Eur J Pharmacol. 1990 Nov 6;190(1-2):235-8. doi: 10.1016/0014-2999(90)94131-g.
The acquisition of a visuo-tactile simultaneous discrimination task for food reward was evaluated in male albino rats given 0, 120, 240 and 360 mg/kg of l-glutamic acid diethyl ester, an antagonist of quisqualate and kainate receptors. There was an increase in the number of trials to reach the criterion and in the number of errors at the two highest doses of l-glutamic acid diethyl ester in comparison to the two lowest doses. These results indicate a possible role for non-NMDA amino acid receptors in discrimination learning.
在给予0、120、240和360毫克/千克的L-谷氨酸二乙酯（一种quisqualate和kainate受体拮抗剂）的雄性白化大鼠中，评估了它们获取用于食物奖励的视觉-触觉同时辨别任务的能力。与两个最低剂量相比，在L-谷氨酸二乙酯的两个最高剂量下，达到标准所需的试验次数和错误次数均有所增加。这些结果表明非NMDA氨基酸受体在辨别学习中可能发挥作用。
