Freed W J, Wyatt R J
Pharmacol Biochem Behav. 1981 Feb;14(2):223-6. doi: 10.1016/0091-3057(81)90247-1.
Glutamic acid diethyl ester (GDEE), a putative antagonist of glutamate-induced neuronal excitations, was administered prior to an instrumental conditioning task motivated by food reinforcement. A profound impairment of learning was produced in animals receiving 240 or 480 mg/kg of GDEE. Performance was not impaired by GDEE in rats that had previously learned the task. These findings support suggestions that central excitatory processes play an important role in learning phenomena, in particular when these learning phenomena involve acquisition of new behavioral patterns.
谷氨酸二乙酯（GDEE）是一种推测的谷氨酸诱导神经元兴奋的拮抗剂，在由食物强化驱动的操作性条件任务之前给药。接受240或480mg/kg GDEE的动物出现了严重的学习障碍。GDEE对先前已学会该任务的大鼠的行为表现没有损害。这些发现支持了这样的观点，即中枢兴奋过程在学习现象中起着重要作用，特别是当这些学习现象涉及新行为模式的习得时。
