Rolandi E, Franceshini R, Cataldi A, Barreca T
Department of Internal Medicine, University of Genoa, Italy.
Gerontology. 1990;36(5-6):356-60. doi: 10.1159/000213221.
A chronobiological study was carried out in 8 elderly male subjects (74-85 years) to evaluate the 24-hour vasoactive intestinal polypeptide (VIP) secretory pattern. Eight young adult males (21-32 years) made up the control group. Blood samples were drawn from each subject every 2 h during the day and hourly during the night for a 24-hour period. Mean 24-hour VIP values in elderly (21.1 +/- 0.3 pg/ml) and young adults (19.1 +/- 0.3 pg/ml) did not differ statistically, but daytime VIP values observed in elderly subjects (21.4 +/- 0.5 pg/ml) were higher (p less than 0.05) than those recorded in young adults (17.5 +/- 0.5 pg/ml). The young adults showed significant (p less than 0.05) circadian VIP fluctuations with highest values during the nighttime, while the elderly subjects did not. An age-related decreased activity of the peripheral neuronal VIP-ergic network is hypothesized.
对8名老年男性受试者（74 - 85岁）进行了一项时间生物学研究，以评估24小时血管活性肠肽（VIP）的分泌模式。8名年轻成年男性（21 - 32岁）组成对照组。在24小时内，白天每2小时从每个受试者采集一次血样，夜间每小时采集一次。老年人（21.1±0.3 pg/ml）和年轻人（19.1±0.3 pg/ml）的24小时平均VIP值在统计学上没有差异，但老年受试者白天的VIP值（21.4±0.5 pg/ml）高于年轻人（17.5±0.5 pg/ml）（p<0.05）。年轻成年人显示出显著的（p<0.05）昼夜VIP波动，夜间值最高，而老年受试者则没有。推测外周神经元VIP能网络的活性存在与年龄相关的下降。
