Barreca T, Franceschini R, Messina V, Bottaro L, Rolandi E
Gerontology. 1985;31(2):119-23. doi: 10.1159/000212690.
A chronobiological study was carried out in 10 elderly male subjects (78-83 years) to evaluate the 24-hour thyroid-stimulating hormone (TSH) secretory pattern. 10 young adult males (26-35 years) made up the control group. Hourly blood samples were drawn from each subject for a 24-hour period. TSH levels in elderly subjects showed blunted circadian fluctuations compared to those seen in young adult subjects. Mean 24-hour TSH values in elderly (3.1 +/- 0.3 microU/ml) and young adult subjects (3.5 +/- 0.1 microU/ml) did not differ statistically, but nighttime TSH values observed in elderly subjects (3.2 +/- 0.3 microU/ml) were lower (p less than 0.05) than those recorded in young adults (4.1 +/- 0.1 microU/ml).
对10名老年男性受试者（78 - 83岁）进行了一项时间生物学研究，以评估24小时促甲状腺激素（TSH）的分泌模式。10名年轻成年男性（26 - 35岁）组成对照组。在24小时内，每小时从每个受试者采集血样。与年轻成年受试者相比，老年受试者的TSH水平昼夜波动减弱。老年受试者（3.1±0.3微国际单位/毫升）和年轻成年受试者（3.5±0.1微国际单位/毫升）的24小时平均TSH值在统计学上无差异，但老年受试者夜间TSH值（3.2±0.3微国际单位/毫升）低于（p<0.05）年轻成年人记录的值（4.1±0.1微国际单位/毫升）。
