静息代谢率、身体成分与甲状腺激素。极低热量饮食的短期影响。

Resting metabolic rate, body composition and thyroid hormones. Short term effects of very low calorie diet.

作者信息

Cavallo E, Armellini F, Zamboni M, Vicentini R, Milani M P, Bosello O

机构信息

Institute of Clinica Medica, University of Verona, Italy.

出版信息

Horm Metab Res. 1990 Dec;22(12):632-5. doi: 10.1055/s-2007-1004990.

DOI:10.1055/s-2007-1004990

PMID:2076860

Abstract

27 obese women (relative body weight 191 +/- 27%), aged 35 +/- 11, underwent a 15 day very low calorie diet (VLCD: 1337 kJ/day). Mean body weight loss was 6 +/- 1.5 kg. Resting metabolic rate (RMR), measured by indirect calorimetry, showed a significant decrease both in absolute values (from 1793 +/- 225 to 1569 +/- 231 kcal/day; P less than 0.001), and in keal/kg body weight/day (from 17 +/- 2, to 16 +/- 2, P less than 0.001). Serum triiodothyronine (T3) significantly decreased from 1.1 +/- 0.2 to 1 +/- 0.2 microgram/1 (P less than 0.001). Before VLCD the differences between measured RMR and theoretical RMR (RMR-T) were not significant. After VLCD RMR values were significantly (P less than 0.001) lower than RMR-T. It was concluded that fat-free mass loss, combined with periferic thyroxin (T4) reduced monodeiodination in its more active form mainly due to low calorie intake T3 could be responsible for the important reduction observed in the resting metabolic rate.

摘要

27名肥胖女性（相对体重191±27%），年龄35±11岁，接受了为期15天的极低热量饮食（VLCD：1337千焦/天）。平均体重减轻6±1.5千克。通过间接测热法测量的静息代谢率（RMR），无论是绝对值（从1793±225千卡/天降至1569±231千卡/天；P<0.001），还是千卡/千克体重/天（从17±2降至16±2，P<0.001）均显著下降。血清三碘甲状腺原氨酸（T3）从1.1±0.2微克/升显著降至1±0.2微克/升（P<0.001）。在VLCD之前，测量的RMR与理论RMR（RMR-T）之间的差异不显著。VLCD后，RMR值显著低于RMR-T（P<0.001）。得出的结论是，无脂肪体重减轻，加上外周甲状腺素（T4）向其更活跃形式的单碘脱碘减少，主要是由于低热量摄入，T3可能是静息代谢率显著降低的原因。