Zukerberg L R, Armin A R, Pisharodi L, Young R H
Department of Pathology, Massachusetts General Hospital, Boston 02114.
Histopathology. 1990 Nov;17(5):407-11. doi: 10.1111/j.1365-2559.1990.tb00760.x.
We report two transitional cell carcinomas of the urinary bladder containing numerous osteoclast-type giant cells that stained for vimentin and acid phosphatase (with and without tartrate) and were negative for cytokeratin and lysozyme. One tumour, in a 65-year-old man, was composed of papillary transitional cell carcinoma, invasive poorly differentiated carcinoma with a prominent spindle cell component and numerous osteoclast-type giant cells; repeat curettage 2 months later showed no residual tumour. The second tumour occurred in a 75-year-old woman who underwent a radical cystectomy for a deeply invasive transitional cell carcinoma with a spindle and anaplastic giant cell component and areas containing numerous osteoclast-type giant cells. Osteoclast-type giant cells, which appear to be reactive, should be distinguished from the neoplastic giant cells of giant cell carcinoma.
我们报告了两例膀胱移行细胞癌，其中含有大量破骨细胞型巨细胞，这些巨细胞波形蛋白和酸性磷酸酶（含或不含酒石酸盐）染色阳性，细胞角蛋白和溶菌酶染色阴性。一例发生于一名65岁男性，由乳头状移行细胞癌、具有显著梭形细胞成分的浸润性低分化癌以及大量破骨细胞型巨细胞组成；2个月后再次刮宫显示无残留肿瘤。第二例发生于一名75岁女性，因深部浸润性移行细胞癌伴梭形和间变性巨细胞成分以及含有大量破骨细胞型巨细胞的区域而接受了根治性膀胱切除术。破骨细胞型巨细胞似乎是反应性的，应与巨细胞癌的肿瘤性巨细胞相鉴别。
