Himal H S, Rudick J
Am J Gastroenterol. 1977 Jun;67(6):574-9.
Effect of isosmotic biocarbonate-rich solutions on the Brunner's gland area were studied by means of proximal duodenal explants in eight anesthetized dogs. Volume gain occurred with all instillates and varied indirectly with the concentration of the bicarbonate in the instilled solutions. Net bicarbonate gain occurred with instillate of 40 mEq./1.; net insorption occurred with instillates of higher bicarbonate concentration, the rate of which was dependent on the instillate concentration. Insorption of chloride occurred with the lower bicarbonate solutions and enterosorption occurred at higher concentrations. The modification of intraluminal bicarbonate by the proximal duodenal mucosa is important in the regulation of intraduodenal pH and abnormal function of this mechanism may play a role in the pathogenesis of duodenal ulceration because of incomplete hydrochloric acid neutralization.
通过对八只麻醉犬的十二指肠近端外植体进行研究，观察等渗富碳酸氢盐溶液对十二指肠腺区域的影响。所有灌流液均出现容量增加，且与灌流液中碳酸氢盐浓度呈间接变化关系。当灌流液为40 mEq./1.时出现净碳酸氢盐增加；当灌流液中碳酸氢盐浓度较高时出现净吸收，其速率取决于灌流液浓度。较低碳酸氢盐溶液时出现氯吸收，较高浓度时出现肠吸收。十二指肠近端黏膜对腔内碳酸氢盐的调节对于十二指肠内pH的调节很重要，该机制的异常功能可能由于盐酸中和不完全而在十二指肠溃疡的发病机制中起作用。
