HIV-1 protease as a potential target for anti-AIDS therapy.

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超能文献

作者信息

Meek T D, Dreyer G B

机构信息

Department of Medicinal Chemistry, Smith Kline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.

出版信息

Ann N Y Acad Sci. 1990;616:41-53. doi: 10.1111/j.1749-6632.1990.tb17826.x.

DOI:10.1111/j.1749-6632.1990.tb17826.x

PMID:2078031

Abstract

摘要

相似文献

HIV-1 protease as a potential target for anti-AIDS therapy.

Ann N Y Acad Sci. 1990;616:41-53. doi: 10.1111/j.1749-6632.1990.tb17826.x.

The HIV-1 protease as a therapeutic target for AIDS.

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Inhibitors of HIV-1 protease.HIV-1蛋白酶抑制剂。

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[Inhibitors of HIV-1 reverse transcriptase and protease as chemotherapeutics for AIDS].[作为艾滋病化疗药物的HIV-1逆转录酶和蛋白酶抑制剂]

Nihon Rinsho. 1991 Sep;49(9):2062-9.

The evaluation of non-viral substrates of the HIV protease as leads in the design of inhibitors for AIDS therapy.对HIV蛋白酶的非病毒底物作为艾滋病治疗抑制剂设计先导物的评估。

Adv Exp Med Biol. 1991;306:469-82. doi: 10.1007/978-1-4684-6012-4_60.

Potent HIV-1 protease inhibitors with antiviral activities in vitro.

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Viral proteases as targets for chemotherapeutic intervention.作为化疗干预靶点的病毒蛋白酶。

Curr Opin Biotechnol. 1992 Dec;3(6):643-9. doi: 10.1016/0958-1669(92)90010-g.

HIV protease: a novel chemotherapeutic target for AIDS.

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[More drugs against HIV/AIDS will soon be available as a review over the drug development shows].随着对药物研发的审查表明，很快将会有更多抗艾滋病毒/艾滋病的药物可供使用。

Lakartidningen. 1991 Nov 27;88(48):4139-42.

HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.基于羟乙烯二肽电子等排体的HIV-1蛋白酶抑制剂：P1'侧链对构效关系作用的研究

J Med Chem. 1992 May 15;35(10):1702-9. doi: 10.1021/jm00088a004.

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3'-Tetrahydrofuranylglycine as a Novel, Unnatural Amino Acid Surrogate for Asparagine in the Design of Inhibitors of the HIV Protease.3'-四氢呋喃基甘氨酸作为一种新型非天然氨基酸替代物用于设计HIV蛋白酶抑制剂中的天冬酰胺。

J Am Chem Soc. 1993 Jan 1;115(2):801-803. doi: 10.1021/ja00055a069.

Fluorescent-conjugated polymer superquenching facilitates highly sensitive detection of proteases.荧光共轭聚合物超猝灭有助于蛋白酶的高灵敏度检测。

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7511-5. doi: 10.1073/pnas.0402367101. Epub 2004 May 10.

Analysis of resistance to human immunodeficiency virus type 1 protease inhibitors by using matched bacterial expression and proviral infection vectors.利用匹配的细菌表达载体和前病毒感染载体分析对1型人类免疫缺陷病毒蛋白酶抑制剂的耐药性。

J Virol. 1995 Sep;69(9):5431-6. doi: 10.1128/JVI.69.9.5431-5436.1995.

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