Michel P, Rasoamanana B, Raharison Vololoarisoa H, Randriamahefa J G, Coulanges P
Arch Inst Pasteur Madagascar. 1990;57(1):265-95.
Plague is a bacterial disease, induced by Yersinia pestis growth in rodents, with human transmission by fleas. In numerous cases, lymph node reaction is important. This survey (329 patients and contacts) is the most extensive ever realised, associating plasmidic virulence and immunity studies. From the results, we can retain that: All the strains were 47 Plasmid+. The immunity was precocious, specific, of high titer and persistent. In conclusion, in plaque endemic zone, high bacillus circulation induced a high and perhaps (to prove) protective immunity.
鼠疫是一种细菌性疾病，由鼠疫耶尔森菌在啮齿动物体内生长引发，通过跳蚤在人与人之间传播。在许多病例中，淋巴结反应很重要。这项调查（涉及329名患者及接触者）是有史以来规模最大的，将质粒毒力和免疫研究结合在一起。从结果来看，我们可以得出：所有菌株均携带47质粒。免疫力出现较早、具有特异性、效价高且持久。总之，在鼠疫流行区，高杆菌传播引发了高水平且可能（有待证实）具有保护性的免疫力。
