Lefvert A K, Bergström K, Matell G, Osterman P O, Pirskanen R
J Neurol Neurosurg Psychiatry. 1978 May;41(5):394-403. doi: 10.1136/jnnp.41.5.394.
Antibodies to cholinergic receptor structures were found in 75% of 76 Finnish and 93% of 175 Swedish patients with myasthenia gravis. The amount of antibodies showed a positive correlation to the severity of the disease, and was reduced during immunosuppressive treatment, and by thymectomy. Thymoma patients had high values. The antibody was also found in the cerebrospinal fluid. Two healthy newborn babies of myasthenic mothers had antibodies during the first weeks of life, in spite of no clinical symptoms. The occurrence of IgM antibodies before IgM antibodies in two patients during the early stages of myasthenia gravis suggests that the antibody is not a primary cause of the disease.
在76名芬兰重症肌无力患者中，75%发现了针对胆碱能受体结构的抗体；在175名瑞典重症肌无力患者中，93%发现了此类抗体。抗体数量与疾病严重程度呈正相关，在免疫抑制治疗期间以及胸腺切除术后会减少。胸腺瘤患者的抗体值较高。在脑脊液中也发现了该抗体。两名患重症肌无力母亲的健康新生儿在出生后的头几周内虽无临床症状，但也有抗体。两名重症肌无力早期患者先出现IgM抗体，后出现IgG抗体，这表明该抗体并非疾病的主要病因。
