Seybold M E, Baergen R N, Nave B, Lindstrom J M
Br Med J. 1978 Oct 14;2(6144):1051-3. doi: 10.1136/bmj.2.6144.1051.
Serum concentrations of anti-acetylcholine-receptor (anti-AChR) antibody were measured in patients with myasthenia gravis. In those patients undergoing thymectomy concentrations were measured before and after the operation to see whether there might be a connection between the thymus and antibody production. We found no correlation between antibody concentration and either thymectomy or duration and severity of the disease before the operation. Our results suggest that if anti-AChR antibodies are the principal pathogenic factor in myasthenia gravis then immunological and neurophysical variables other than the total serum anti-AChR antibody concentration contribute to the severity of the disease.
对重症肌无力患者测定了血清抗乙酰胆碱受体（抗AChR）抗体浓度。对于那些接受胸腺切除术的患者，在手术前后均进行了浓度测定，以观察胸腺与抗体产生之间是否可能存在关联。我们发现抗体浓度与胸腺切除术、术前疾病持续时间及严重程度之间均无相关性。我们的结果表明，如果抗AChR抗体是重症肌无力的主要致病因素，那么除了血清抗AChR抗体总浓度之外的免疫和神经物理变量也会影响疾病的严重程度。
