Gomikawa S, Okada M
J Nutr Sci Vitaminol (Tokyo). 1978;24(1):25-34. doi: 10.3177/jnsv.24.25.
Lipid metabolism was examined in rats fed a high-protein pyridoxine-deficient diet, and their livers were found to contain large amounts of lipids, mainly in the forms of triglycerides and cholesteryl ester. The contents of ketone bodies in the livers of pyridoxine-deficient and the control rats were similar. Their NAD+/NADH ratios, calculated from the amounts of ketone bodies, were also similar in pyridoxine-deficient and control groups when the animals were fed, but the ratio in pyridoxine-deficient rats was lower than that of control rats when the animals were starved. After injection of 14C-linoleic acid, the amounts of expired 14CO2 in pyridoxine-deficient and control rats were similar. The pattern of incorporations of 14C-linoleic acid into various lipid components of the livers were examined; incorporation into the phospho-lipid fraction was similar in control and deficient rats, but the incorporation into the triglyceride fraction was slower, and the incorporation into cholesterol was faster in deficient animals than in controls.
对喂食高蛋白吡哆醇缺乏饮食的大鼠的脂质代谢进行了研究，发现它们的肝脏含有大量脂质，主要以甘油三酯和胆固醇酯的形式存在。吡哆醇缺乏大鼠和对照大鼠肝脏中的酮体含量相似。当动物进食时，根据酮体含量计算出的它们的NAD+/NADH比值在吡哆醇缺乏组和对照组中也相似，但当动物饥饿时，吡哆醇缺乏大鼠的该比值低于对照大鼠。注射14C-亚油酸后，吡哆醇缺乏大鼠和对照大鼠呼出的14CO2量相似。研究了14C-亚油酸掺入肝脏各种脂质成分的模式；对照大鼠和缺乏大鼠中掺入磷脂部分的情况相似，但缺乏大鼠中掺入甘油三酯部分的速度较慢，而掺入胆固醇的速度比对照大鼠快。
