Naggar V F, Khalil S A, Gouda M W
J Pharm Sci. 1978 Jul;67(7):1029-30. doi: 10.1002/jps.2600670746.
The oral absorption of dexamethasone in humans was compared to its absorption when coadministered with magnesium trisilicate. The bioavailability of dexamethasone was estimated by measuring the suppressive effect of the drug on the daily excretion of endogenous steroids. Administration of 1 mg of dexamethasone to six healthy male volunteers significantly decreased the urinary excretion of 11-hydroxycorticosteroids. However, the coadministration of magnesium trisilicate with dexamethasone decreased its absorption, as indicated by the increased urinary excretion of 11-hydroxycorticosteroids. The decrease in absorption was attributed to drug adsorption on the antacid surface. These results confirm previous in vitro findings.
将地塞米松在人体中的口服吸收情况与其与三硅酸镁共同给药时的吸收情况进行了比较。通过测量该药物对内源性类固醇每日排泄的抑制作用来估算地塞米松的生物利用度。给6名健康男性志愿者服用1毫克地塞米松可显著降低11-羟基皮质类固醇的尿排泄量。然而，三硅酸镁与地塞米松共同给药会降低其吸收，这表现为11-羟基皮质类固醇的尿排泄量增加。吸收的降低归因于药物在抗酸剂表面的吸附。这些结果证实了先前的体外研究结果。
