Babhair S A, Tariq M
Res Commun Chem Pathol Pharmacol. 1983 Apr;40(1):165-8.
Variability in the bioavailability of orally administered trimethoprim due to Magnesium trisilicate and Kaolin-pectin has been investigated. The concentration of trimethoprim in blood was determined spectrofluorometrically at 0, 15 and 30 minutes and 1, 2, 4 and 6 hours. The area under the blood concentration curve of trimothoprim was significantly decreased, when the drug was given concurrently with magnesium trisilicate or kaolin-pectin. The mean decrease in maximum blood concentration of trimethoprim in magnesium trisilicate and kaolin-pectin treated groups was 49.94% and 29.42% respectively. The data suggest that a clinically significant interaction may occur due to concurrent administration of trimethoprim with these drugs.
已对硅酸镁和高岭土果胶导致口服甲氧苄啶生物利用度的变异性进行了研究。采用荧光分光光度法在0、15和30分钟以及1、2、4和6小时测定血液中甲氧苄啶的浓度。当该药物与硅酸镁或高岭土果胶同时给药时，甲氧苄啶的血药浓度曲线下面积显著降低。在硅酸镁和高岭土果胶治疗组中，甲氧苄啶的最大血药浓度平均降低分别为49.94%和29.42%。数据表明，甲氧苄啶与这些药物同时给药可能会发生具有临床意义的相互作用。
