Roper R E, Salem M G
Br J Anaesth. 1981 Dec;53(12):1277-80. doi: 10.1093/bja/53.12.1277.
Glycopyrrolate, atropine or saline were administered i.v. with oral magnesium trisilicate 1 h before induction of anaesthesia to patients about to undergo Caesarean section. Both anticholinergics greatly reduced gastric acidity. It is suggested that glycopyrrolate should be used in combination with antacid therapy before obstetric anaesthesia and puerperal tubal ligation because of its prolonged duration of action, effect on gastric secretion and failure to cross the placental barrier.
在即将接受剖宫产手术的患者中，于麻醉诱导前1小时静脉注射格隆溴铵、阿托品或生理盐水，并口服三硅酸镁。两种抗胆碱能药物均能大幅降低胃酸度。鉴于格隆溴铵作用持续时间长、对胃液分泌有影响且不能透过胎盘屏障，建议在产科麻醉和产后输卵管结扎前将其与抗酸治疗联合使用。
