Riekkinen P, Sirviö J, Miettinen R, Riekkinen P
Department of Neurology, University of Kuopio, Finland.
Brain Res. 1990 Aug 27;526(1):31-6. doi: 10.1016/0006-8993(90)90246-8.
In the present study we compared the effects of an ibotenic acid lesion of the nucleus basalis magnocellularis (NBM), a 5,7-dihydroxytryptamine lesion of the raphe dorsalis (RD) and a combined RD and NBM lesion on the regulation of neocortical electrical activity in freely moving rat. NBM lesions (choline acetyltransferase decrease: frontal cortex 29%, occipital cortex 23%) increased both slow wave amplitudes and waking immobility-related high-voltage spindles (HVS). Although RD lesions (serotonin decrease: frontal cortex 67%, occipital cortex 68%) alone did not affect neocortical electrical activity, the lesion aggravated the increase of HVSs induced by an NBM lesion. The present results demonstrate an interaction between the RD and NBM in regulating cortical functions.
在本研究中，我们比较了大细胞基底核（NBM）的鹅膏蕈氨酸损伤、背侧中缝核（RD）的5,7-二羟基色胺损伤以及RD和NBM联合损伤对自由活动大鼠新皮质电活动调节的影响。NBM损伤（胆碱乙酰转移酶减少：额叶皮质29%，枕叶皮质23%）增加了慢波振幅和与清醒不动相关的高电压纺锤波（HVS）。虽然单独的RD损伤（5-羟色胺减少：额叶皮质67%，枕叶皮质68%）不影响新皮质电活动，但该损伤加剧了由NBM损伤诱导的HVS增加。目前的结果表明，RD和NBM在调节皮质功能方面存在相互作用。
