Calder I C, Funder C C, Green C R, Ham K N, Tange J D
Br Med J. 1972 Jan 15;1(5793):152-4. doi: 10.1136/bmj.1.5793.152.
5-Aminosalicylic acid given to rats as a single intravenous injection led to necrosis of the proximal convoluted tubules and of the renal papilla. These two lesions developed at the same time and the cortical lesions did not appear to be a consequence of the renal papillary necrosis. Since the compound possesses the molecular structure both of a phenacetin derivative and of a salicylate these observations may be relevant to the problem of renal damage incident to abuse of analgesic compounds and suggest the possibility that in this syndrome cortical lesions may develop independently of renal papillary necrosis.
给大鼠单次静脉注射5-氨基水杨酸会导致近端曲管和肾乳头坏死。这两种损伤同时出现，皮质损伤似乎并非肾乳头坏死的结果。由于该化合物具有非那西丁衍生物和水杨酸盐的分子结构，这些观察结果可能与滥用止痛化合物所致肾损伤问题相关，并提示在该综合征中皮质损伤可能独立于肾乳头坏死而发生。
