对氨基酚诱导大鼠产生的肾脏病变。

Green C R, Ham K N, Tange J D

Br Med J. 1969 Jan 18;1(5637):162-4. doi: 10.1136/bmj.1.5637.162.

Necrosis of the terminal third of the proximal convulated tubule develops in rats after a single intravenous injection of p-aminophenol hydrochloride. As the tubules regenerate a chronic inflammatory reaction occurs in the interstitial tissue, and this reaction extends beyond the original zone of injury. These findings are additional evidence that some aromatic compounds are selectively nephrotoxic and may be particularly relevant to the problem of renal damage associated with heavy and prolonged doses of analgesics.

大鼠单次静脉注射对氨基苯酚盐酸盐后，近端曲管终末三分之一段会发生坏死。随着肾小管再生，间质组织会出现慢性炎症反应，且这种反应会延伸至原始损伤区域之外。这些发现进一步证明，某些芳香族化合物具有选择性肾毒性，可能与长期大量服用镇痛药导致的肾损伤问题尤为相关。