Arfiero S, Ometto R, Vincenzi M
Divisione clinicizzata di Cardiologia, Ospedale S. Bortolo, Vicenza, Università di Verona.
G Ital Cardiol. 1990 Sep;20(9):869-72.
The authors report the case of an 84-year-old man with mild aortic valvular disease and arterial hypertension who developed marked QT interval prolongation and several lipotimic and syncopal attacks after 3 months of treatment with ketanserin (40 mg/day). The correlation between ketanserin, QT prolongation and symptoms was assessed by withdrawal and subsequent re-administration of the drug. Continuous ECG monitoring revealed the occurrence of QT prolongation and symptomatic runs of torsade de pointes ventricular tachycardia. The Authors suggest that treatment with ketanserin needs careful patients selection and follow-up.
作者报告了一名84岁男性患者的病例，该患者患有轻度主动脉瓣疾病和动脉高血压，在使用酮色林（40毫克/天）治疗3个月后出现明显的QT间期延长以及多次脂质性晕厥和晕厥发作。通过停药和随后重新给药来评估酮色林、QT延长与症状之间的相关性。连续心电图监测显示出现QT延长和尖端扭转型室性心动过速的症状性发作。作者建议，使用酮色林治疗需要谨慎选择患者并进行随访。
