Heitkemper D, Creed J, Caruso J A
Department of Chemistry, University of Cincinnati, OH 45221.
J Chromatogr Sci. 1990 Apr;28(4):175-81. doi: 10.1093/chromsci/28.4.175.
Reversed-phase high-performance liquid chromatography (HPLC) is directly coupled to helium microwave-induced plasma mass spectrometry (He MIP-MS) for the element-selective detection of halogenated organic compounds. Absolute detection limits are approximately 50 pg Br for brominated compounds, 1 pg I for iodinated compounds, and 10 ng Cl for chlorinated compounds. The linear dynamic range for Br- and I-containing compounds is 3-4 orders of magnitude. However, the linear range for chlorinated species is severely limited by high background at m/z = 35. The relative standard deviation for repetitive injections is less than 10%. The helium microwave-induced plasma is operated at moderate powers (300-350 W) and with a total helium consumption of 6-8 L/min. The effect of organic solvents on the background mass spectrum is investigated.
反相高效液相色谱法（HPLC）直接与氦微波诱导等离子体质谱法（He MIP-MS）联用，用于卤代有机化合物的元素选择性检测。对于溴化化合物，绝对检测限约为50 pg Br；对于碘化化合物，为1 pg I；对于氯化化合物，为10 ng Cl。含Br和I的化合物的线性动态范围为3 - 4个数量级。然而，由于m/z = 35处的高背景，氯化物的线性范围受到严重限制。重复进样的相对标准偏差小于10%。氦微波诱导等离子体在中等功率（300 - 350 W）下运行，氦气总消耗量为6 - 8 L/min。研究了有机溶剂对背景质谱的影响。
