NMI Natural and Medical Sciences Institute at the University of Tübingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany.
Nano Lett. 2010 Oct 13;10(10):3933-9. doi: 10.1021/nl1016909.
Microstructured 20 μm thick polymer filaments used as nerve implants were loaded with chitosan/siRNA nanoparticles to promote nerve regeneration and ensure local delivery of nanotherapeutics. The stable nanoparticles were rapidly internalized by cells and did not affect cell viability. Target mRNA was successfully reduced by 65-75% and neurite outgrowth was enhanced even in an inhibitory environment. This work, thus, supports the application of nanobiofunctionalized implants as a novel approach for spinal cord and nerve repair.
用作神经植入物的 20μm 厚微结构聚合物细丝负载壳聚糖/siRNA 纳米颗粒，以促进神经再生并确保纳米药物的局部递送。稳定的纳米颗粒被细胞迅速内化，并且不影响细胞活力。靶 mRNA 成功降低了 65-75%，并且即使在抑制环境中也增强了神经突生长。因此，这项工作支持将纳米生物功能化植入物作为脊髓和神经修复的新方法的应用。
Zotero 插件