Centre of Polymer Systems, Tomas Bata University in Zlín, 760 01 Zlín, Czech Republic.
Department of Experimental Biology, Faculty of Science, Masaryk University, 625 00 Brno, Czech Republic.
Int J Mol Sci. 2021 Jan 6;22(2):501. doi: 10.3390/ijms22020501.
The active role of biomaterials in the regeneration of tissues and their ability to modulate the behavior of stem cells in terms of their differentiation is highly advantageous. Here, polypyrrole, as a representantive of electro-conducting materials, is found to modulate the behavior of embryonic stem cells. Concretely, the aqueous extracts of polypyrrole induce neurogenesis within embryonic bodies formed from embryonic stem cells. This finding ledto an effort to determine the physiological cascade which is responsible for this effect. The polypyrrole modulates signaling pathways of Akt and ERK kinase through their phosphorylation. These effects are related to the presence of low-molecular-weight compounds present in aqueous polypyrrole extracts, determined by mass spectroscopy. The results show that consequences related to the modulation of stem cell differentiation must also be taken into account when polypyrrole is considered as a biomaterial.
生物材料在组织再生中的积极作用及其调节干细胞分化行为的能力具有很大的优势。在这里，聚吡咯作为导电材料的代表，被发现可以调节胚胎干细胞的行为。具体来说，聚吡咯的水提物诱导由胚胎干细胞形成的胚胎体中的神经发生。这一发现促使人们努力确定负责这种效应的生理级联反应。聚吡咯通过磷酸化调节 Akt 和 ERK 激酶的信号通路。这些效应与通过质谱确定的聚吡咯水提物中存在的低分子量化合物有关。结果表明，当聚吡咯被视为生物材料时，必须考虑到与调节干细胞分化相关的后果。
Zotero 插件
