Information & Quantum Systems Laboratory, Hewlett-Packard Laboratories, 1501 Page Mill Road, MS1123, Palo Alto, California 94304, USA.
J Am Chem Soc. 2010 Sep 22;132(37):12820-2. doi: 10.1021/ja105248h.
Here we demonstrate a molecular trap structure that can be formed to capture analyte molecules in solution for detection and identification. The structure is based on gold-coated nanoscale polymer fingers made by nanoimprinting technique. The nanofingers are flexible and their tips can be brought together to trap molecules, while at the same time the gold-coated fingertips form a reliable Raman hot spot for molecule detection and identification based on surface enhanced Raman spectroscopy (SERS). The molecule self-limiting gap size control between fingertips ensures ultimate SERS enhancement for sensitive molecule detection. Furthermore, these type of structures, resulting from top-down meeting self-assembly, can be generalized for other applications, such as plasmonics, meta-materials, and other nanophotonic systems.
在这里，我们展示了一种分子捕获结构，可以形成这种结构来捕获溶液中的分析物分子，以进行检测和识别。该结构基于通过纳米压印技术制成的涂金纳米级聚合物指状物。纳米指状物具有柔韧性，其尖端可以聚集在一起以捕获分子，同时涂金的指尖形成基于表面增强拉曼光谱（SERS）的可靠拉曼热点，用于分子检测和识别。分子自限制指尖之间的间隙尺寸控制可确保对敏感分子进行超灵敏的检测增强。此外，源自自上而下的自组装的这种类型的结构可以推广应用于其他领域，例如等离子体学、超材料和其他纳米光子系统。
