State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China.
Vector Borne Zoonotic Dis. 2011 Mar;11(3):215-21. doi: 10.1089/vbz.2009.0225. Epub 2010 Aug 26.
Streptococcus suis serotype 2 (S. suis S2) is able to cause human infections ranging from superficial wounded skin infections to severe invasive infections such as meningitis and streptococcal toxic shock-like syndrome. During its infection cycle, S. suis S2 must acclimatize itself to temperature shift. Herein, a whole-genome DNA microarray was used to investigate the global transcriptional regulation of an invasive strain of S. suis S2 grown to late-exponential phase at 29°C or 40°C relative to 37°C. The differentially regulated genes that were detected included those encoding virulence factors, antigenic proteins, ATP-binding-cassette transporters, and proteins of unknown functions. Our data provided a global profile of gene transcription induced by temperature alteration and shed light on some unforeseen lines for further pathogenesis investigation.
猪链球菌 2 型（S. suis S2）能够引起人类感染，从浅表创伤皮肤感染到严重的侵袭性感染，如脑膜炎和链球菌中毒性休克样综合征。在其感染周期中，S. suis S2 必须适应温度变化。在此，使用全基因组 DNA 微阵列来研究在 29°C 或 40°C 下生长至晚期指数期的侵袭性 S. suis S2 菌株相对于 37°C 的全局转录调控。检测到的差异调节基因包括编码毒力因子、抗原蛋白、ATP 结合盒转运蛋白和未知功能的蛋白质的基因。我们的数据提供了由温度变化诱导的基因转录的全局图谱，并为进一步的发病机制研究提供了一些意想不到的线索。
