（p）ppGpp及其同源物对链球菌环境适应性、生存能力和致病性的调控
Regulation of (p)ppGpp and Its Homologs on Environmental Adaptation, Survival, and Pathogenicity of Streptococci.
作者信息
Zhang Tengfei, Zhu Jiawen, Xu Jiajia, Shao Huabin, Zhou Rui
机构信息
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs), Institute of Animal and Veterinary Science, Hubei Academy of Agricultural Sciences, Wuhan, China.
出版信息
Front Microbiol. 2020 Sep 25;11:1842. doi: 10.3389/fmicb.2020.01842. eCollection 2020.
Most streptococci are commensals, pathogens, or opportunistic pathogens for humans and animals. Therefore, it is important for streptococci to adapt to the various challenging environments of the host during the processes of infection or colonization, as well as to conditions for transmission. Stringent response (SR) is a special class of adaptive response induced by the signal molecules (p)ppGpp, which regulate several physiological aspects, such as long-term persistence, virulence, biofilm formation, and quorum sensing in bacteria. To understand the roles of SR in streptococci, the current mini-review gives a general overview on: (1) (p)ppGpp synthetases in the genus of , (2) the effects of (p)ppGpp on the physiological phenotypes, persistence, and pathogenicity of streptococci, (3) the transcriptional regulation induced by (p)ppGpp in streptococci, and (4) the link between (p)ppGpp and another nutrient regulatory protein CodY in streptococci.
大多数链球菌是人类和动物的共生菌、病原菌或机会致病菌。因此，对于链球菌来说，在感染或定植过程中适应宿主的各种挑战性环境以及传播条件非常重要。严谨反应（SR）是由信号分子（p）ppGpp诱导的一类特殊的适应性反应，它调节细菌的几个生理方面，如长期存活、毒力、生物膜形成和群体感应。为了了解SR在链球菌中的作用，本综述简要概述了：（1）链球菌属中的（p）ppGpp合成酶；（2）（p）ppGpp对链球菌生理表型、存活和致病性的影响；（3）（p）ppGpp在链球菌中诱导的转录调控；（4）（p）ppGpp与链球菌中另一种营养调控蛋白CodY之间的联系。
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