低甲胎蛋白肝细胞癌。
Low alpha-fetoprotein hepatocellular carcinoma.
机构信息
Liver Tumor Program of Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
出版信息
J Gastroenterol Hepatol. 2010 Sep;25(9):1543-9. doi: 10.1111/j.1440-1746.2010.06303.x.
BACKGROUND AND AIM
A large proportion of hepatocellular carcinoma (HCC) patients do not secrete elevated levels of the tumor marker alpha-fetoprotein (AFP). There is little published guide to prognostic features of this patient subset.
METHODS
We interrogated a large HCC database in which all patients had been followed until death, to examine which features might be prognostically useful.
RESULTS
We found 413 biopsy-proven unresectable HCC patients with low serum AFP values. Serum gamma glutamyl transpeptidase (GGTP) levels were one of the most significant factors for survival. This dichotomization into low and high GGTP levels separated the patients into distinctive survival ranges. Patients with GGTP levels < 110 U/100 mL and small tumors had longest survival > 795 days. Patients with GGTP > or = 110 U/mL and large tumors with the presence of portal vein thrombosis had the shortest survival range of 300-560 days.
CONCLUSIONS
Serum levels of the onco-fetal protein GGTP represent a useful prognostic parameter in HCC patients with low AFP levels.
背景与目的
相当一部分肝细胞癌（HCC）患者的肿瘤标志物甲胎蛋白（AFP）水平并未升高。对于这部分患者亚群的预后特征，目前发表的相关指南较少。
方法
我们对一个大型 HCC 数据库进行了分析，该数据库中的所有患者均随访至死亡，以检查哪些特征可能具有预后价值。
结果
我们发现 413 例经活检证实的不可切除 HCC 患者血清 AFP 值较低。血清γ-谷氨酰转肽酶（GGTP）水平是影响生存的最重要因素之一。根据 GGTP 水平将患者分为低水平和高水平两组，两组患者的生存范围明显不同。GGTP 水平<110 U/100 mL 且肿瘤较小的患者生存时间最长，超过 795 天；而 GGTP 水平≥110 U/mL 且肿瘤较大且存在门静脉血栓形成的患者生存时间最短，为 300-560 天。
结论
血清 GGTP 等胎儿蛋白水平是 AFP 水平较低的 HCC 患者的一个有用的预后参数。
Zotero 插件