Gattanell P N, Perloff M, Holland J F
Med Pediatr Oncol. 1978;4(2):99-103. doi: 10.1002/mpo.2950040203.
A case of hepatocellular carcinoma in a young female is presented in which the apparent etiology was the use of oral contraceptives for 5 1/2 years. Sequential therapeutic trials with intraarterial 5-fluorouracil, intraarterial adriamycin, and intravenous 1,3 bis[2-chloroethyl]-1-nitrosourea (BCNU) were unsuccesful. The adverse effects of oral contraceptives on the structure and function of hepatic tissue are reviewed.
本文报告了一例年轻女性肝细胞癌病例，其明显病因是服用了5年半的口服避孕药。先后进行了动脉内注射5-氟尿嘧啶、动脉内注射阿霉素以及静脉注射1,3-双（2-氯乙基）-1-亚硝基脲（卡氮芥）的治疗试验，但均未成功。本文还综述了口服避孕药对肝组织结构和功能的不良影响。
