Kalra T M, Mangla J C, DePapp E W
Am J Med. 1976 Dec;61(6):871-7. doi: 10.1016/0002-9343(76)90411-3.
In order to consider possible environmental factors related to the development of benign hepatic tumors, all reports of this disorder in the case records of five different hospitals in Rochester, New York, during the past 10 years were reviewed. Seven patients with benign hepatic tumors of the liver and two with peliosis hepatis were identified. Among the seven with a benign hepatic tumor, four were women currently receiving oral contraceptives; one had been receiving this medication in the past, and two had no history of exposure to any steroid whatsoever. The two patients with peliosis hepatis were receiving long-term androgenic anabolic steroids. Dilated, thin-walled vessels and vascular spaces were a more prominent feature of the tumor seen in four patients receiving oral contraceptive pills. It is emphasized in this report that benign hepatic tumors do occur in men and in patients with cirrhotic liver without the use of any kind of steroids.
为了探究与良性肝肿瘤发生相关的潜在环境因素，我们回顾了纽约罗切斯特市五家不同医院过去10年病例记录中所有关于该疾病的报告。共识别出7例肝良性肿瘤患者和2例肝紫癜患者。在7例肝良性肿瘤患者中，4例为正在服用口服避孕药的女性；1例曾服用过此药物，2例无任何类固醇接触史。2例肝紫癜患者正在接受长期雄激素类合成代谢类固醇治疗。在4例服用口服避孕药的患者所患肿瘤中，扩张的薄壁血管和血管间隙是更突出的特征。本报告强调，良性肝肿瘤确实会发生在男性以及未使用任何类固醇的肝硬化患者中。
