Jiang Zhijian, Wang Xiaoping
The Chencun Hospital of Foshan City, Foshan 528313, China.
Zhongguo Fei Ai Za Zhi. 2008 Dec 20;11(6):793-7. doi: 10.3779/j.issn.1009-3419.2008.06.05.
It has been proven that PTEN and nm23-H1 genes were the tumor metastasis suppressor genes. Up to now, most of studies are aim at basic research. The aim of this study is to explore the level of expression of PTEN and nm23-H1 protein in non-small cell lung cancer and their relationship to the clinical significance of non-small cell lung cancer.
An immunohistochemical method was used to detect the expression of PTEN and nm23-H1 protein in 60 cases of non-small cell lung cancer.
In the groups with and without lymph nodes metastasis, the positive rates of PTEN protein expression were 41.94% and 79.31% respectively. The difference between them was significant (P <0.01). The rates of positive expression of nm23-H1 protein were 45.16% and 82.76% respectively. The difference between them also was significant (P <0.01). The expression of PTEN was relatively consistent with that of nm23-H1 (Kappa =0.436 6, Z =3.390 5, P <0.01).
The expressions of PTEN and nm23-H1 in NSCLC were closely related to lymph nodes metastasis. Combining detection of these two proteins might be more helpful for evaluating lymph nodes metastasis and predicting the prognosis.
已证实PTEN和nm23-H1基因是肿瘤转移抑制基因。到目前为止，大多数研究都集中在基础研究方面。本研究旨在探讨PTEN和nm23-H1蛋白在非小细胞肺癌中的表达水平及其与非小细胞肺癌临床意义的关系。
采用免疫组织化学方法检测60例非小细胞肺癌中PTEN和nm23-H1蛋白的表达。
有淋巴结转移组和无淋巴结转移组中，PTEN蛋白阳性表达率分别为41.94%和79.31%。两者差异有统计学意义（P<0.01）。nm23-H1蛋白阳性表达率分别为45.16%和82.76%。两者差异也有统计学意义（P<0.01）。PTEN与nm23-H1的表达具有较好的一致性（Kappa=0.436 6，Z=3.390 5，P<0.01）。
NSCLC中PTEN和nm23-H1的表达与淋巴结转移密切相关。联合检测这两种蛋白可能更有助于评估淋巴结转移及预测预后。
