Universidade Federal do Rio Grande do Sul. Porto Alegre, RS 90035-003, Brazil.
Reprod Biomed Online. 2010 Oct;21(4):470-3. doi: 10.1016/j.rbmo.2010.05.007. Epub 2010 May 24.
This cross-sectional prospective study assessed follicular-fluid anti-Müllerian hormone (AMH) concentrations in infertile patients with mild/minimal endometriosis during natural IVF. Thirty-two women participated in the study. Patients were divided into two groups: tubal obstruction without endometriosis (control group) and minimal/mild endometriosis (study group). All patients underwent laparoscopy for assessment of infertility; at the same time, any foci of endometriosis found were cauterized. AMH concentration was measured in the follicular fluid of a single follicle when it achieved pre-ovulatory maturation by ultrasensitive enzyme-linked immunosorbent assay. Likewise, AMH, FSH and inhibin B content in serum was also measured. Age (30 ± 1.3 and 32 ± 0.8 years) and body mass index (22 ± 0.6 and 22 ± 0.5 kg/m(2)), day-3 antral follicle count (11.3 ± 1.7 and 10.7 ± 1.5), serum FSH concentrations (5.4 ± 0.6 and 5.0 ± 0.3 IU/ml) and follicular-fluid AMH concentrations (1.8 ± 0.3 and 1.5 ± 0.1 ng/ml, study and control group, respectively; mean difference 0.33, 95% CI -0.21 to 0.88) were similar in both groups. This study shows that infertile patients with minimal/mild endometriosis have a similar concentration of AMH in the follicular fluid after natural IVF as compared with control subjects.
这项横断面前瞻性研究评估了自然体外受精（IVF）中轻度/微小子宫内膜异位症不孕患者的卵泡液抗苗勒管激素（AMH）浓度。32 名女性参与了这项研究。患者分为两组：无输卵管阻塞的子宫内膜异位症（对照组）和微小/轻度子宫内膜异位症（研究组）。所有患者均接受腹腔镜检查评估不孕情况；同时，对发现的任何子宫内膜异位症病灶进行电灼。通过超敏酶联免疫吸附试验测量单个卵泡达到排卵前成熟时的卵泡液中 AMH 浓度。同样，也测量血清中的 AMH、FSH 和抑制素 B 含量。年龄（30±1.3 岁和 32±0.8 岁）和体重指数（22±0.6kg/m2 和 22±0.5kg/m2）、窦卵泡计数（第 3 天）（11.3±1.7 个和 10.7±1.5 个）、血清 FSH 浓度（5.4±0.6IU/ml 和 5.0±0.3IU/ml）和卵泡液 AMH 浓度（1.8±0.3ng/ml 和 1.5±0.1ng/ml，研究组和对照组；平均差值 0.33，95%CI-0.21 至 0.88）在两组中相似。这项研究表明，与对照组相比，轻度/微小子宫内膜异位症的不孕患者在自然 IVF 后卵泡液中的 AMH 浓度相似。
