Mother-Infant Department, Institute of Obstetrics and Gynecology, University of Modena and Reggio Emilia, 41100 Modena, Italy.
Reprod Biomed Online. 2010 Oct;21(4):463-9. doi: 10.1016/j.rbmo.2010.05.009. Epub 2010 May 24.
Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.
抗缪勒管激素（AMH）已成为生殖内分泌领域的“热门分子”。事实上，它在提高对卵巢病理生理学的认识以及指导广泛的疾病的临床管理方面具有重要价值。然而，目前尚未建立健康女性的循环 AMH 的正常值。在这项横断面研究中，纳入了 277 名健康女性（年龄 18-50 岁）。采用商业酶联免疫吸附测定法测量 AMH。血清 AMH 浓度随女性年龄增长而逐渐下降。AMH 的年龄相关性变化最适合用多项式函数拟合。过去使用口服避孕药不会改变 AMH 的浓度，而且与女性的产次无关。建立了循环 AMH 浓度的年龄特异性正常值。AMH 浓度似乎与患者的生育史无关。
