Department of Obstetrics, Gynaecology and Reproductive Medicine, Archet II Hospital, University of Nice-Sophia-Antipolis, 151 Rte St Antoine de Ginestiere, 06202 Nice Cedex 3, France.
Hum Reprod. 2011 Dec;26(12):3431-6. doi: 10.1093/humrep/der320. Epub 2011 Oct 3.
Anti-Müllerian hormone (AMH) levels are used to evaluate the ovarian reserve. AMH serum concentrations have recently been studied among women attending fertility centers, and among women with regular menstrual cycles but normative values have not been established among fertile women: the objective of this study was to establish those values.
This prospective cross-sectional study included 340 healthy fertile women attending a single centre, aged between 15 and 50 years. The women were all in the first trimester of pregnancy, had no serious medical history and attended the abortion service of the University Hospital of Nice, France. Serum AMH was measured using a second-generation AMH enzyme-linked immunosorbent assay.
Median AMH concentration was 2.42 ng/ml (25-75 percentiles 1.19-4.12). The relationship between AMH concentration and age was best fitted by a polynomial function. Serum AMH values rose until age 29 years and then showed a significant decline (R(2)= 0.289, P < 0.001). Normative values for serum AMH were established in different age groups between 15 and 50 years.
We established the normative values for serum AMH in a population of French fertile women in their first trimester of pregnancy.
抗苗勒氏管激素（AMH）水平用于评估卵巢储备功能。最近已经在前往生育中心的女性和月经周期正常的女性中研究了 AMH 血清浓度，但尚未在生育力正常的女性中建立正常值：本研究的目的是建立这些值。
这项前瞻性的横断面研究纳入了 340 名年龄在 15 至 50 岁之间的健康生育力正常的法国尼斯大学附属医院流产服务中心就诊的初孕妇。使用第二代 AMH 酶联免疫吸附测定法测量血清 AMH。
中位 AMH 浓度为 2.42ng/ml（25-75 百分位为 1.19-4.12）。AMH 浓度与年龄之间的关系最佳拟合多项式函数。血清 AMH 值在 29 岁之前升高，然后显著下降（R(2)=0.289，P<0.001）。在 15 至 50 岁的不同年龄组中建立了血清 AMH 的正常值。
我们在初孕妇中建立了法国生育力正常女性的血清 AMH 正常值。
