Graduate School of Bio-Agricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Science. 2010 Aug 27;329(5995):1065-7. doi: 10.1126/science.1191132.
Stem cells are maintained in the niche by intercellular interactions and signaling networks. In this work, we study extracellular signals required for maintenance of the root stem cell niche in higher plants. We identify a family of functionally redundant homologous peptides that are secreted, tyrosine-sulfated, and expressed mainly in the stem cell area and the innermost layer of central columella cells. We name these peptides root meristem growth factors (RGFs). RGFs are required for maintenance of the root stem cell niche and transit amplifying cell proliferation in Arabidopsis. RGF1 defines expression levels and patterns of the stem cell transcription factor PLETHORA, mainly at the posttranscriptional level. The RGFs function independently of the auxin pathway. These peptide signals play a crucial role in postembryonic root development.
干细胞由细胞间相互作用和信号网络维持在龛位中。在这项工作中，我们研究了维持高等植物根干细胞龛所必需的细胞外信号。我们鉴定了一组功能冗余的同源肽，这些肽是分泌的、酪氨酸硫酸化的，主要在干细胞区域和中央柱状细胞的最内层表达。我们将这些肽命名为根分生组织生长因子（RGFs）。RGFs 是维持根干细胞龛和拟南芥中转导扩增细胞增殖所必需的。RGF1 主要在转录后水平定义干细胞转录因子 PLETHORA 的表达水平和模式。RGFs 独立于生长素途径发挥作用。这些肽信号在胚胎后根发育中起着至关重要的作用。
