Fielder Jon, Rambiki Kelvin
Partners in Hope Medical Center, Lilongwe, Malawi, Africa.
J Int Assoc Physicians AIDS Care (Chic). 2010 Jul-Aug;9(4):236-9. doi: 10.1177/1545109710373830.
Fixed-dose combinations containing stavudine have played a critical role in the worldwide scale-up of antiretroviral therapy, but increasing concern exists regarding adverse events due to mitochondrial toxicity. We describe the first reported occurrence of lactic acidosis within a family of 3 HIV-infected individuals. This report is only the second of lactic acidosis affecting an African child. Further research is indicated to identify possible genetic and other risk factors underlying mitochondrial toxicity in African populations, especially among pediatric cohorts.
含司他夫定的固定剂量复方制剂在全球扩大抗逆转录病毒治疗规模中发挥了关键作用，但因线粒体毒性导致的不良事件引发了越来越多的关注。我们描述了首例在一个3名感染HIV的家庭成员中发生乳酸酸中毒的报告。该报告是第二例影响非洲儿童的乳酸酸中毒病例。有必要进行进一步研究，以确定非洲人群，尤其是儿科队列中线粒体毒性潜在的可能遗传和其他风险因素。
