Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea.
J Microbiol Biotechnol. 2010 Aug;20(8):1189-91. doi: 10.4014/jmb.1004.04028.
In an ongoing investigation of compounds from natural products that exhibit anti-aging properties, hydroxyhibiscone A (1), a new furanosesquiterpenoid, together with hibiscone D (2), was isolated from the root bark of Hibiscus syriacus. Utilizing UV, IR, NMR, and MS spectroscopic analyses, these chemical structures were revealed. Compounds 1 and 2 were found to possess significant anti-aging properties on the human neutrophil elastase (HNE) assay, exhibiting HNE inhibitory activities with IC50 values of 5.2 and 4.6 micronM, respectively.
在一项对具有抗衰老特性的天然产物化合物的持续研究中，从木槿（Hibiscus syriacus）根皮中分离得到了羟基蝴蝶酸 A（1），一种新的呋喃倍半萜，以及蝴蝶酸 D（2）。利用 UV、IR、NMR 和 MS 光谱分析揭示了这些化学结构。化合物 1 和 2 在人中性粒细胞弹性蛋白酶（HNE）测定中表现出显著的抗衰老特性，对 HNE 的抑制活性的 IC50 值分别为 5.2 和 4.6 microM。
