School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Molecules. 2013 Jun 27;18(7):7549-56. doi: 10.3390/molecules18077549.
Spatholobus suberectus Dunn, belonging to the legume family (Fabaceae), has been used as a Traditional Chinese Medicine for the treatment of anemia, menoxenia and rheumatism. A limited number of studies report that various types of flavonoids are the main characteristic constituents of this herb. We have now found that S. suberectus contains about 2% phenolic components and characterized the major phenolic components as homogeneous B-type procyanidin conjugates using a liquid chromatography with diode-array detection-ESI mass spectrometry (LC-DAD/ESI-MS) method. This is the first report on occurrence of most B-type procyanidins in this herb. Moreover, the total phenolics extract was assayed for inhibitory activity on human neutrophil elastase and its IC₅₀ was found to be 1.33 μg/mL.
鸡血藤，属于豆科（Fabaceae）植物，被用作治疗贫血、月经不调和风湿的传统中药。少数研究报告指出，多种类型的黄酮类化合物是这种草药的主要特征成分。我们现在发现，鸡血藤含有约 2%的酚类成分，并使用液相色谱-二极管阵列检测-电喷雾质谱（LC-DAD/ESI-MS）方法将主要的酚类成分鉴定为均一的 B 型原花青素缀合物。这是该草药中存在大多数 B 型原花青素的首次报道。此外，对总酚提取物进行了人中性粒细胞弹性蛋白酶抑制活性测定，其 IC₅₀值为 1.33μg/mL。
