在趋化作用过程中，突触融合蛋白介导的囊泡融合的内运动和超越运动。
Movement within and movement beyond: synaptotagmin-mediated vesicle fusion during chemotaxis.
机构信息
Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Cell Adh Migr. 2011 Jan-Feb;5(1):56-8. doi: 10.4161/cam.5.1.13197. Epub 2011 Jan 1.
Abstract
Leukocyte chemotaxis plays an essential role in generating and delivering immune responses and is a critical component of inflammation. In order to identify novel genes and pathways important for regulating chemotaxis, we performed an RNAi-based screen and identified several genes involved with vesicle movement and fusion as mediators of chemotaxis. Our recently published data show that during chemotaxis vesicle trafficking proteins are required for lysosome fusion, uropod release and efficient directed cell migration.
摘要
白细胞趋化作用在产生和传递免疫反应中起着至关重要的作用，是炎症的关键组成部分。为了鉴定调控趋化作用的新基因和途径，我们进行了基于 RNAi 的筛选，并发现了几个与囊泡运动和融合有关的基因，它们作为趋化作用的介质。我们最近发表的数据表明，在趋化作用过程中，囊泡运输蛋白对于溶酶体融合、尾足释放和有效的定向细胞迁移是必需的。
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本文引用的文献
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Nat Immunol. 2010 Jun;11(6):495-502. doi: 10.1038/ni.1878. Epub 2010 May 16.
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