UCT/MRC Research Unit for Exercise Science and Sports Medicine of the Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Med Sci Sports Exerc. 2011 Apr;43(4):584-9. doi: 10.1249/MSS.0b013e3181f34f4d.
Running economy, a key component of endurance ability, has been shown to be associated with flexibility. Increased stiffness (inflexibility) may improve running economy and therefore endurance running ability. The COL5A1 gene, which encodes the α1-chain of type V collagen, was found to associate with measures of flexibility. Type V collagen is a quantitatively minor fibrillar collagen, which is believed to regulate fibrillogenesis within tendons and other connective tissue.
The aim of this study was therefore to determine whether the COL5A1 gene is associated with endurance performance.
Three hundred thirteen Caucasian male participants who completed either the 2006 or the 2007 226-km South African Ironman triathlon (3.8-km swim, 180-km bike, and 42.2-km run) participated in this study. All participants were genotyped for the COL5A1 BstUI restriction fragment length polymorphism (RFLP).
The COL5A1 BstUI RFLP was significantly associated with time to complete the running component of the triathlon. Participants with a TT genotype completed the running component of the race significantly faster than individuals with a CC genotype (P = 0.019; mean ± SD: TT = 294.2 ± 52.1 min, CC = 307.4 ± 48.6 min). In addition, there was a significant linear trend (P = 0.020) in the CC genotype distribution when the run times were divided into the fastest (13%), middle (17%), and slowest (25%) tertiles. There were no significant genotype differences for time to complete the swim, the bike, or the overall race. COL5A1 BstUI RFLP, body mass index, age, and 15 wk of running training history predicted 30% of the variance in running performance.
This is the first study to identify the COL5A1 BstUI RFLP as a marker for endurance running performance. Further studies are required to replicate these findings.
跑步经济性是耐力能力的一个关键组成部分，已被证明与柔韧性有关。增加僵硬度（柔韧性降低）可能会提高跑步经济性，从而提高耐力跑步能力。COL5A1 基因编码类型 V 胶原的α1 链，已被发现与柔韧性测量值相关。类型 V 胶原是一种定量较少的纤维胶原，据信它可调节肌腱和其他结缔组织中的原纤维形成。
本研究旨在确定 COL5A1 基因是否与耐力表现相关。
313 名完成 2006 年或 2007 年南非铁人三项 226 公里赛（3.8 公里游泳、180 公里自行车和 42.2 公里跑步）的白种男性参与者参加了这项研究。所有参与者均接受 COL5A1 BstUI 限制性片段长度多态性（RFLP）的基因分型。
COL5A1 BstUI RFLP 与铁人三项跑步项目的完成时间显著相关。TT 基因型的参与者完成比赛的跑步部分明显快于 CC 基因型的个体（P=0.019；平均值±标准差：TT=294.2±52.1 分钟，CC=307.4±48.6 分钟）。此外，当跑步时间分为最快（13%）、中间（17%）和最慢（25%）三分位数时，CC 基因型的分布呈现出显著的线性趋势（P=0.020）。游泳、自行车或整体比赛的完成时间没有明显的基因型差异。COL5A1 BstUI RFLP、体重指数、年龄和 15 周的跑步训练历史可预测跑步表现的 30%方差。
这是第一项确定 COL5A1 BstUI RFLP 作为耐力跑步表现的标志物的研究。需要进一步的研究来复制这些发现。
