Lund University, Department of Oncology, Lund, Sweden.
J Biomed Opt. 2010 Jul-Aug;15(4):041502. doi: 10.1117/1.3466579.
Photodynamic therapy (PDT) is reviewed using the treatment of skin tumors as an example of superficial lesions and prostate cancer as an example of deep-lying lesions requiring interstitial intervention. These two applications are among the most commonly studied in oncological PDT, and illustrate well the different challenges facing the two modalities of PDT-superficial and interstitial. They thus serve as good examples to illustrate the entire field of PDT in oncology. PDT is discussed based on the Lund University group's over 20 yr of experience in the field. In particular, the interplay between optical diagnostics and dosimetry and the delivery of the therapeutic light dose are highlighted. An interactive multiple-fiber interstitial procedure to deliver the required therapeutic dose based on the assessment of light fluence rate and sensitizer concentration and oxygen level throughout the tumor is presented.
光动力疗法 (PDT) 以皮肤肿瘤的治疗为例进行了综述，皮肤肿瘤是一种浅层病变，而前列腺癌则是需要介入治疗的深层病变。这两种应用是肿瘤学 PDT 中研究最多的两种，它们很好地说明了 PDT 两种方式——浅层和介入的不同挑战。因此，它们是很好的例子，可以说明整个肿瘤学 PDT 领域。本文基于隆德大学研究小组 20 多年的研究经验，讨论了 PDT。特别强调了光学诊断和剂量学以及治疗光剂量传递之间的相互作用。提出了一种交互式多光纤介入程序，根据肿瘤内的光辐照度率、敏化剂浓度和氧水平的评估，来传递所需的治疗剂量。
