Algorri José Francisco, López-Higuera José Miguel, Rodríguez-Cobo Luís, Cobo Adolfo
Photonics Engineering Group, University of Cantabria, 39005 Santander, Spain.
CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain.
Pharmaceutics. 2023 Aug 3;15(8):2075. doi: 10.3390/pharmaceutics15082075.
Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death. The foundations of modern photodynamic therapy began in the late 19th and early 20th centuries, and in recent times, it has gained more attention due to the development of new sources and PSs. This review focuses on the latest advancements in light technology for PDT in treating skin cancer lesions. It discusses recent research and developments in light-emitting technologies, their potential benefits and drawbacks, and their implications for clinical practice. Finally, this review summarizes key findings and discusses their implications for the use of PDT in skin cancer treatment, highlighting the limitations of current approaches and providing insights into future research directions to improve both the efficacy and safety of PDT. This review aims to provide a comprehensive understanding of PDT for skin cancer treatment, covering various aspects ranging from the underlying mechanisms to the latest technological advancements in the field.
光动力疗法（PDT）是一种越来越受欢迎的皮肤科治疗方法，不仅用于威胁生命的皮肤疾病和其他肿瘤，还用于美容目的。PDT对底层功能结构的影响可忽略不计，使组织再生成为可能。PDT使用光敏剂（PS）和可见光来产生细胞毒性活性氧，其可损害细胞器并触发细胞死亡。现代光动力疗法的基础始于19世纪末和20世纪初，近年来，由于新光源和光敏剂的发展，它受到了更多关注。本综述重点关注用于治疗皮肤癌病变的光动力疗法的光技术的最新进展。它讨论了发光技术的最新研究和发展、它们的潜在益处和缺点以及它们对临床实践的影响。最后，本综述总结了关键发现，并讨论了它们对光动力疗法在皮肤癌治疗中的应用的影响，强调了当前方法的局限性，并为未来的研究方向提供了见解，以提高光动力疗法的疗效和安全性。本综述旨在全面了解用于皮肤癌治疗的光动力疗法，涵盖从潜在机制到该领域最新技术进展的各个方面。
