Department of Surgery & The Alvin J Siteman Cancer Center, Washington University School of Medicine, Rm. 5026, St. Louis, MO 63110, USA.
Future Oncol. 2010 Aug;6(8):1289-311. doi: 10.2217/fon.10.95.
Since the early 1950s when sexually transmitted infections (STIs) were first proposed as a possible risk factor for prostate cancer, numerous epidemiologic studies have been conducted. Initially, these studies were primarily small case-control studies with retrospective, self-reported assessments of a narrow range of STIs, typically either any STIs, or gonorrhea and syphilis. However, as new STIs have been discovered/recognized, new and better tests to detect histories of STIs have been developed, and new resources for prostate cancer research have been created, epidemiologic studies have expanded to include a wide range of STIs, and have moved towards more rigorous, prospective study designs and serological assessment of STI histories. The results of these studies are reviewed and discussed, as well as possible new avenues of research, such as Trichomonas vaginalis infection and infections not typically considered to be sexually transmitted.
自 20 世纪 50 年代首次提出性传播感染（STIs）可能是前列腺癌的一个风险因素以来，已经进行了大量的流行病学研究。最初，这些研究主要是小型病例对照研究，采用回顾性、自我报告的方式评估范围较窄的 STIs，通常是任何 STIs 或淋病和梅毒。然而，随着新的 STIs 的发现/认识，用于检测 STIs 病史的新的和更好的检测方法已经得到开发，并且为前列腺癌研究创造了新的资源，流行病学研究已经扩展到包括广泛的 STIs，并朝着更严格、前瞻性的研究设计和 STIs 病史的血清学评估方向发展。对这些研究的结果进行了回顾和讨论，以及可能的新的研究途径，如阴道毛滴虫感染和通常不被认为是性传播的感染。
