MTHFR C677T 和 A1298C 多态性的协同作用对伊朗 2 型糖尿病患者微量和大量白蛋白尿风险的增加及糖尿病肾病进展的影响。
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.
机构信息
Department of Endocrinology, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
出版信息
Clin Biochem. 2010 Nov;43(16-17):1333-9. doi: 10.1016/j.clinbiochem.2010.08.019. Epub 2010 Aug 25.
OBJECTIVES
To find whether polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C are risk factors for diabetic nephropathy (DN) among type 2 diabetes mellitus (T2DM) patients from Western Iran.
DESIGN AND METHODS
The MTHFR polymorphisms were detected in 72 microalbuminuric, 68 macroalbuminuric and 72 normoalbuinuric T2DM patients by PCR-RFLP.
RESULTS
The possession of both MTHFR 677T and 1298C alleles increase the risk of microalbuminuria to 4.3-fold (p=0.007) in T2DM patients. The presence of either MTHFR 677T, 1298C allele is sufficient to increase the risk of macroalbuminuria in T2DM patients by 4.1 and 5.5 times (p=0.027, and p=0.006, respectively). The concomitant presence of both 677T and 1298C alleles act in synergy to increase the risk of macroalbuminuria by 20.4-fold (p<0.001) and progression of DN from microalbuminuria to macroalbuminuria (OR=4.73, p=0.01).
CONCLUSION
Both MTHFR 677T and 1298C alleles increased the susceptibility to the onset and progression of DN in Iranians with T2DM.
目的
在来自伊朗西部的 2 型糖尿病（T2DM）患者中，寻找亚甲基四氢叶酸还原酶（MTHFR）C677T 和 A1298C 多态性是否为糖尿病肾病（DN）的危险因素。
设计和方法
通过 PCR-RFLP 检测 72 例微量白蛋白尿、68 例大量白蛋白尿和 72 例正常白蛋白尿的 T2DM 患者的 MTHFR 多态性。
结果
同时携带 MTHFR 677T 和 1298C 等位基因会使 T2DM 患者发生微量白蛋白尿的风险增加 4.3 倍（p=0.007）。仅携带 MTHFR 677T、1298C 等位基因就足以使 T2DM 患者发生大量白蛋白尿的风险分别增加 4.1 倍和 5.5 倍（p=0.027 和 p=0.006）。同时携带这两个等位基因的协同作用会使大量白蛋白尿的风险增加 20.4 倍（p<0.001），并且使从微量白蛋白尿到大量白蛋白尿的 DN 进展风险增加 4.73 倍（p=0.01）。
结论
MTHFR 677T 和 1298C 等位基因均会增加伊朗 T2DM 患者发生 DN 的易感性和进展。
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