• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis.亚洲人群中MTHFR基因C677T多态性与2型糖尿病肾病：一项荟萃分析
Int J Clin Exp Med. 2015 Mar 15;8(3):3662-70. eCollection 2015.
2
Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus.2型糖尿病患者亚甲基四氢叶酸还原酶（MTHFR）C677T基因多态性与糖尿病肾病易感性
Ren Fail. 2015;37(8):1247-59. doi: 10.3109/0886022X.2015.1064743. Epub 2015 Jul 10.
3
Association between end-stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms.终末期糖尿病肾病与亚甲基四氢叶酸还原酶（MTHFR，C677T和A1298C）基因多态性之间的关联
Nephrology (Carlton). 2019 Feb;24(2):155-159. doi: 10.1111/nep.13208.
4
C677T and A1298C methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, bipolar disorder and depression: a meta-analysis of genetic association studies.精神分裂症、双相情感障碍和抑郁症中C677T及A1298C亚甲基四氢叶酸还原酶基因多态性：遗传关联研究的荟萃分析
Psychiatr Genet. 2006 Jun;16(3):105-15. doi: 10.1097/01.ypg.0000199444.77291.e2.
5
MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients.MTHFR基因C677T和A1298C多态性及高同型半胱氨酸血症作为2型糖尿病患者糖尿病肾病的危险因素
Diabetes Res Clin Pract. 2007 Jan;75(1):99-106. doi: 10.1016/j.diabres.2006.05.018. Epub 2006 Jul 7.
6
Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: a systematic review and meta-analysis.亚甲基四氢叶酸还原酶（MTHFR）C677T/A1298C基因多态性与原发性高血压之间的关联：一项系统评价和荟萃分析。
Metabolism. 2014 Dec;63(12):1503-11. doi: 10.1016/j.metabol.2014.10.001.
7
[The association of methylenetetrahydrofolate reductase gene polymorphism with nephropathy in type 2 diabetes mellitus in Chinese].[亚甲基四氢叶酸还原酶基因多态性与中国2型糖尿病肾病的关联]
Zhonghua Nei Ke Za Zhi. 2001 Aug;40(8):529-32.
8
Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis.亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与男性不育风险的关联：一项荟萃分析。
Eur J Obstet Gynecol Reprod Biol. 2017 May;212:101-109. doi: 10.1016/j.ejogrb.2017.03.004. Epub 2017 Mar 4.
9
Methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy: a meta-analysis.亚甲基四氢叶酸还原酶基因多态性作为糖尿病肾病的危险因素：一项荟萃分析
J Hum Genet. 2007;52(11):881-890. doi: 10.1007/s10038-007-0189-3. Epub 2007 Sep 6.
10
Methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and susceptibility to Parkinson's disease: a meta-analysis.亚甲基四氢叶酸还原酶（MTHFR）C677T/A1298C 多态性与帕金森病易感性的关系：荟萃分析。
J Neurol Sci. 2013 Dec 15;335(1-2):14-21. doi: 10.1016/j.jns.2013.09.006. Epub 2013 Sep 12.

引用本文的文献

1
Assessing the possible association between MTHFR (rs1801133) and GPx-1 (rs1050450) polymorphisms with the risk of type 2 diabetes, diabetic neuropathy, and diabetic retinopathy.评估 MTHFR(rs1801133)和 GPx-1(rs1050450)多态性与 2 型糖尿病、糖尿病神经病变和糖尿病视网膜病变风险之间的可能关联。
Mol Biol Rep. 2024 Apr 29;51(1):583. doi: 10.1007/s11033-024-09519-0.
2
Genetic Determinants of Cardiovascular Disease: The Endothelial Nitric Oxide Synthase 3 (eNOS3), Krüppel-Like Factor-14 (KLF-14), Methylenetetrahydrofolate Reductase (MTHFR), MiRNAs27a and Their Association with the Predisposition and Susceptibility to Coronary Artery Disease.心血管疾病的遗传决定因素：内皮型一氧化氮合酶3（eNOS3）、类 Kruppel 样因子-14（KLF-14）、亚甲基四氢叶酸还原酶（MTHFR）、微小RNA27a及其与冠状动脉疾病易感性和易患性的关联。
Life (Basel). 2022 Nov 16;12(11):1905. doi: 10.3390/life12111905.
3
Role of metabolizing MTHFR gene polymorphism (rs1801133) and its mRNA expression among Type 2 Diabetes.代谢型亚甲基四氢叶酸还原酶（MTHFR）基因多态性（rs1801133）及其mRNA表达在2型糖尿病中的作用
J Diabetes Metab Disord. 2022 Feb 19;21(1):511-516. doi: 10.1007/s40200-022-01001-7. eCollection 2022 Jun.
4
Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.亚甲基四氢叶酸还原酶（MTHFR）、一碳循环与心血管风险
Nutrients. 2021 Dec 20;13(12):4562. doi: 10.3390/nu13124562.
5
Decisive evidence corroborates a null relationship between MTHFR C677T and chronic kidney disease: A case-control study and a meta-analysis.决定性证据证实亚甲基四氢叶酸还原酶C677T与慢性肾脏病之间不存在关联：一项病例对照研究及荟萃分析。
Medicine (Baltimore). 2020 Jul 17;99(29):e21045. doi: 10.1097/MD.0000000000021045.
6
The single nucleotide polymorphism rs11643718 in SLC12A3 is associated with the development of diabetic kidney disease in Chinese people with type 2 diabetes.SLC12A3 基因上的单核苷酸多态性 rs11643718 与中国 2 型糖尿病患者糖尿病肾病的发生有关。
Diabet Med. 2020 Nov;37(11):1879-1889. doi: 10.1111/dme.14364. Epub 2020 Jul 23.
7
Association of Two Methylenetetrahydrofolate Reductase Polymorphisms (rs1801133, rs1801131) with the Risk of Type 2 Diabetes in South-East of Iran.伊朗东南部两种亚甲基四氢叶酸还原酶多态性（rs1801133、rs1801131）与2型糖尿病风险的关联
Rep Biochem Mol Biol. 2019 Jul;8(2):178-183.
8
Diagnostic value of neutrophil gelatinase-associated lipocalin in diabetic nephropathy: a meta-analysis.中性粒细胞明胶酶相关脂质运载蛋白在糖尿病肾病中的诊断价值：一项荟萃分析。
Ren Fail. 2019 Nov;41(1):489-496. doi: 10.1080/0886022X.2019.1619581.
9
Type II diabetes mellitus and hyperhomocysteinemia: a complex interaction.2型糖尿病与高同型半胱氨酸血症：一种复杂的相互作用。
Diabetol Metab Syndr. 2017 Mar 21;9:19. doi: 10.1186/s13098-017-0218-0. eCollection 2017.

本文引用的文献

1
Diabetic nephropathy and inflammation.糖尿病肾病与炎症
World J Diabetes. 2014 Jun 15;5(3):393-8. doi: 10.4239/wjd.v5.i3.393.
2
Genetic predisposition for development of nephropathy in type 2 diabetes mellitus.2 型糖尿病肾病发生的遗传易感性。
Biochem Genet. 2013 Dec;51(11-12):865-75. doi: 10.1007/s10528-013-9613-x. Epub 2013 Jul 12.
3
[Analysis on relationship of Chinese medicine syndrome pattern with urinary albumin excretion rate and its related factors in early stage diabetic nephropathy].早期糖尿病肾病中医证候与尿白蛋白排泄率及其相关因素的关系分析
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2010 Sep;30(9):912-4.
4
Synergistic effects of the MTHFR C677T and A1298C polymorphisms on the increased risk of micro- and macro-albuminuria and progression of diabetic nephropathy among Iranians with type 2 diabetes mellitus.MTHFR C677T 和 A1298C 多态性的协同作用对伊朗 2 型糖尿病患者微量和大量白蛋白尿风险的增加及糖尿病肾病进展的影响。
Clin Biochem. 2010 Nov;43(16-17):1333-9. doi: 10.1016/j.clinbiochem.2010.08.019. Epub 2010 Aug 25.
5
Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs.MTHFR C677T 变体对黎巴嫩和巴林阿拉伯人糖尿病肾病风险的差异贡献。
Clin Chem Lab Med. 2010 Aug;48(8):1091-4. doi: 10.1515/CCLM.2010.228.
6
Methyltetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia as a novel risk factor for diabetic nephropathy.甲基四氢叶酸还原酶C677T基因突变与高同型半胱氨酸血症作为糖尿病肾病的一种新的危险因素。
Endocrine. 2009 Oct;36(2):255-61. doi: 10.1007/s12020-009-9218-7. Epub 2009 Jul 14.
7
MTHFR gene polymorphism is susceptible to diabetic retinopathy but not to diabetic nephropathy in Japanese type 2 diabetic patients.在日本2型糖尿病患者中，亚甲基四氢叶酸还原酶（MTHFR）基因多态性易患糖尿病视网膜病变，但与糖尿病肾病无关。
J Diabetes Complications. 2008 Mar-Apr;22(2):119-25. doi: 10.1016/j.jdiacomp.2006.12.002.
8
Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review.β2肾上腺素能受体基因多态性与哮喘关联的系统评价和荟萃分析：一项HuGE评价
Am J Epidemiol. 2005 Aug 1;162(3):201-11. doi: 10.1093/aje/kwi184. Epub 2005 Jun 29.
9
Methylenetetrahydrofolate reductase gene polymorphism is not related to diabetic nephropathy in Japanese Type 2 diabetic patients.亚甲基四氢叶酸还原酶基因多态性与日本2型糖尿病患者的糖尿病肾病无关。
Diabet Med. 2004 Sep;21(9):1051-2. doi: 10.1111/j.1464-5491.2004.01192.x.
10
Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients.亚甲基四氢叶酸还原酶基因多态性作为中国2型糖尿病患者糖尿病肾病的危险因素
Diabetes Res Clin Pract. 2004 Jun;64(3):185-90. doi: 10.1016/j.diabres.2003.10.022.

亚洲人群中MTHFR基因C677T多态性与2型糖尿病肾病：一项荟萃分析

MTHFR gene C677T polymorphism and type 2 diabetic nephropathy in Asian populations: a meta-analysis.

作者信息

Chen Haiyan, Wei Fang, Wang Lihua, Wang Zhe, Meng Jia, Jia Lan, Sun Guijiang, Zhang Ruining, Li Bo, Yu Haibo, Pang Haiyan, Bi Xueqing, Dong Hongye, Jiang Aili, Wang Lin

机构信息

The Second Hospital of Tianjin Medical University 23 Pingkiang Road, Hexi District, Tianjin 300211, China.

出版信息

Int J Clin Exp Med. 2015 Mar 15;8(3):3662-70. eCollection 2015.

PMID:26064261
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4443095/
Abstract

BACKGROUND

Many studies have suggested a correlation between the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene and diabetic nephropathy (DN), but their results are inconclusive.

METHODS

To confirm this correlation, we performed a meta-analysis of 15 studies. The dichotomous data are presented as odds ratios (OR) with 95% confidence intervals (CI).

RESULTS

The results of this study suggested that the MTHFR 677 T allele was more likely to increase the risk of DN in Asian (OR = 1.466, 95% CI = 1.143-1.880, P = 0.003), West Asian (OR = 1.750, 95% CI = 1.150-2.664, P = 0.009), and Chinese populations (OR = 2.162, 95% CI = 1.719-2.719, P = 0.001), but not in East Asian or Japanese populations. The carriers of the MTHFR 677 T allele were associated with progression of DN in the "5-10 year duration" group, but not in the "> 10 year duration" group (OR = 2.187, 95% CI = 1.787-2.677, P = 0.001).

CONCLUSION

Development of DN is associated with MTHFR C677T polymorphisms in Asian populations, especially in early type 2 diabetes.

摘要

背景

许多研究表明亚甲基四氢叶酸还原酶（MTHFR）基因的C677T突变与糖尿病肾病（DN）之间存在关联，但结果尚无定论。

方法

为证实这种关联，我们对15项研究进行了荟萃分析。二分数据以比值比（OR）及95%置信区间（CI）表示。

结果

本研究结果表明，MTHFR 677 T等位基因更有可能增加亚洲人群（OR = 1.466，95% CI = 1.143 - 1.880，P = 0.003）、西亚人群（OR = 1.750，95% CI = 1.150 - 2.664，P = 0.009）和中国人群（OR = 2.162，95% CI = 1.719 - 2.719，P = 0.001）患DN的风险，但在东亚或日本人群中并非如此。MTHFR 677 T等位基因携带者在“病程5 - 10年”组中与DN进展相关，但在“病程> 10年”组中并非如此（OR = 2.187，95% CI = 1.787 - 2.677，P = 0.001）。

结论

在亚洲人群中，尤其是在早期2型糖尿病患者中，DN的发生与MTHFR C677T基因多态性有关。