Cancer Epidemiology & Health Services Research Group, Centre for Public Health, Queen's University Belfast, Northern Ireland, United Kingdom.
Cancer Epidemiol. 2010 Oct;34(5):509-15. doi: 10.1016/j.canep.2010.07.006. Epub 2010 Aug 26.
To date a number of studies have examined the association between maternal weight and testicular cancer risk although results have been largely inconsistent. This systematic review and meta-analysis investigated the nature of this association.
Search strategies were conducted in Ovid Medline (1950-2009), Embase (1980-2009), Web of Science (1970-2009), and CINAHL (1937-2009) using keywords for maternal weight (BMI) and testicular cancer.
The literature search produced 1689 hits from which 63 papers were extracted. Only 7 studies met the pre-defined criteria. Random effects meta-analyses were conducted. The combined unadjusted OR (95% CI) of testicular cancer in the highest reported category of maternal BMI compared with the moderate maternal BMI was 0.82 (0.65-1.02). The Cochran's Q P value was 0.82 and the corresponding I(2) was 0%, both indicating very little variability among studies. The combined unadjusted OR (95% CI) for testicular cancer risk in the lowest reported category of maternal BMI compared to a moderate maternal BMI category was 0.88 (0.65-1.20). The Cochran's Q P value was 0.05 and the corresponding I(2) was 54%, indicating evidence of statistical heterogeneity. The combined unadjusted OR (95% CI) of testicular cancer risk per unit increase in maternal BMI was 1.01 (0.97-1.06). The Cochran's Q test had a P value of 0.05 and the corresponding I(2) was 55% indicating evidence of statistical heterogeneity.
This meta-analysis, which included a small number of studies, showed that a higher maternal weight does not increase the risk of testicular cancer in male offspring. Though an inverse association between high maternal BMI and testicular cancer risk was detected, it was not statistically significant. Further primary studies with adjustment for appropriate confounders are required.
迄今为止，已有多项研究探讨了母体体重与睾丸癌风险之间的关系，但结果大多不一致。本系统评价和荟萃分析旨在调查这种关联的性质。
使用 Ovid Medline（1950-2009 年）、Embase（1980-2009 年）、Web of Science（1970-2009 年）和 CINAHL（1937-2009 年）中的关键词，对母体体重（BMI）和睾丸癌相关文献进行检索。
文献检索共产生 1689 个结果，其中提取了 63 篇文献。仅有 7 项研究符合预先设定的标准。进行了随机效应荟萃分析。与中体型母体 BMI 相比，最高报告类别母体 BMI 的睾丸癌的合并未调整 OR（95%CI）为 0.82（0.65-1.02）。Cochran's Q P 值为 0.82，对应的 I(2)为 0%，均表明研究之间的变异性很小。与中体型母体 BMI 相比，最低报告类别母体 BMI 的睾丸癌风险的合并未调整 OR（95%CI）为 0.88（0.65-1.20）。Cochran's Q P 值为 0.05，对应的 I(2)为 54%，表明存在统计学异质性。母体 BMI 每增加一个单位，睾丸癌风险的合并未调整 OR（95%CI）为 1.01（0.97-1.06）。Cochran's Q 检验的 P 值为 0.05，对应的 I(2)为 55%，表明存在统计学异质性。
本荟萃分析纳入了少数几项研究，结果表明，母体体重较高并不会增加男性后代睾丸癌的风险。虽然检测到高母体 BMI 与睾丸癌风险之间存在反比关系，但无统计学意义。需要进一步开展有适当混杂因素调整的原始研究。
